It's tough being a minority in this world. Although technology seems to cross all gender and racial lines, the world of computing seems to leave one distinct group out in the cold: The South Paw. Left handed people are always on the wrong side of the keyboard when it comes to navigating with a computer mouse. Here's four ways to even the score.
1. Switch the primary buttons.
If you're using your mouse on the left side of your keyboard, you're probably using your middle finger to hit the main click button. But it's easy to switch the orientation of the two (and start using your pointer finger to "left" click!). On a PC, go to the mouse properties window and check the “Switch primary and secondary buttons” box:

Macs are known for their one-button mouse, but if you're using a two-clicker, you can switch your buttons' orientation, too. Head to the Keyboard and Mouse menu and choose "Mouse">"Change Primary mouse button to Right."
2. Buy a left-handed ergonomic mouse.
All the mouses we've ever owned were symmetrical, allowing for a quick move from right to left. But if you're craving a hand-molded ergonomic mouse, there's plenty of lefty models out there.
3. Switch to left-oriented pointer icons.
That little arrow pointer icon is always pointing up and to the left, as if coming up from a god-like right hand using a "normal" mouse. If it bothers you, it's easy to switch your PC's default pointer to a left-oriented arrow. Download these left-handed icons from Microsoft, then head to the "pointers" tab of the "mouse properties" window to browse for your new lefty icons:
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Then change each version of the cursor to its new left-handed counterpart:
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4. Rock a lefty pride mouse pad.
Because only lefties are in their right minds.

(Images: Flickr user laughing lizard under license from Creative Commons, How to Geek, Zazzle.com)

Sprout Side Table
Finally. Thank you. I have a question too. A few people at my job were having an argument about the word mouse. Is the plural of mouse, mice or mouses. We were split evenly. I noticed that you used mouses. How do you know that mouses is the correct word?
Trackpads are often lefty-friendly. I have a Magic Trackpad for my Mini, and a trackpad on my Macbook.
I fail at being a lefty. Switching the buttons would only serve to confuse me. I also prefer the ambidextrous style because it does allow me to easily switch from hand to hand (when I'm working through my lunch hour).
I'm a righty but have an RSI so I mouse left. To minimize confusion, I leave everything configured right but move the mouse over. Works great for reducing fatigue and only took a little while to get used to it.