Macs are known for their one-button mouse, but if you're using a two-clicker, you can switch your buttons' orientation, too. Head to the Keyboard and Mouse menu and choose "Mouse">"Change Primary mouse button to Right."
2. Buy a left-handed ergonomic mouse.
All the mouses we've ever owned were symmetrical, allowing for a quick move from right to left. But if you're craving a hand-molded ergonomic mouse, there's plenty of lefty models out there.
3. Switch to left-oriented pointer icons.
That little arrow pointer icon is always pointing up and to the left, as if coming up from a god-like right hand using a "normal" mouse. If it bothers you, it's easy to switch your PC's default pointer to a left-oriented arrow. Download these left-handed icons from Microsoft, then head to the "pointers" tab of the "mouse properties" window to browse for your new lefty icons:
Then change each version of the cursor to its new left-handed counterpart:
4. Rock a lefty pride mouse pad.
Because only lefties are in their right minds.