A trade off to this decor plan? To really make this look work, you need to commit to going fairly minimal with other decor, patterns and colors, letting the artwork "carry" that part of the room.
If you can live with that, otherwise its pretty much all about scale and balance. The key here is getting the dimensions right - the artwork should be really oversized. A good rule of thumb is that the artwork (either one piece or two in combination) be approximately the width of the bed to maintain the balance and dramatic look.
Does anyone have a room like this at home? If so, let us know about it in the comments below - links to photos are welcome!