Salvation Army They take a long list of items including appliances, household goods, clothing and furniture. You can also schedule a pickup online and they'll provide you a receipt for tax purposes.
Out Of The Closet Thrift Stores Some items that Out of The Closet would like; books, tools and artwork. They won't take your mattress or water bed but they do pick up larger items for donation.
Goodwill Unfortunately, you can't schedule pickups with Goodwill anymore but you can drop off items at anyone of their convenient locations. CDs, DVDs and sleeping bags are just a few of the many things they accept--and don't forget to check out their secure paper shredding program once you're done organizing your paperwork.
National Council of Jewish Women One of our favorite places to donate, they accept everything from stuffed animals to cell phones to crutches--and if you can't drop off, they'll pick up your items for free.
Vietnam Veterans of America While they don't accept furniture you can donate just about everything else (the VVA website claims they accept "almost anything"). We were also excited to find out that you can schedule a pickup with the VVA just by calling.
LensCrafters We recently donated our old reading glasses to LensCrafters where they'll revamp your old spectacles and give them to those in need.
Freecycle And if you just can't find the right place to donate your items, freecycle is a great alternative. All you have to do is post your unwanted wares on a local yahoo group through the site--and pretty soon folks will contact you if interested in your stuff.
And don't forget to check out Sonia's post over on Unpluggd where she breaks down places to donate your old gadgets.