Hanging artwork is a huge part of setting up home. Fortunately there are so many different ways to do so and there's honestly no wrong way. However, there are some useful tips and tricks that can help you be as successful as possible during this somewhat daunting task.
One way to make the most impact is to hang artwork gallery style. Combine artwork of all different shapes, sizes and colors together in one large space. If you have your sofa against a wall, that's an ideal space to hang artwork in this style. You have the option of using the same style and color frame for each piece to somewhat unify the pieces or you can mismatch as much as you want.
If you like the look of gallery style but still have one large piece — it's actually rather simple to combine the two looks. Hang the large piece centered above the bed (or any other piece of furniture) and hang the remaining smaller pieces gallery style to the left or right. This will help cover a larger wall or that unique space above a headboard.
Maybe you only have one very large piece that you want to stand alone. Lean it up against the wall on a credenza in the dining room. If it's bold and colorful, make sure the accessories around it are muted so that all eyes are focused on the artwork.