Here's a home office setup which takes the idea of "mood lighting" to the next level, combining an IKEA frosted glass desk with what appears to be IKEA Dioder LED strip lights added underneath, creating an icy-cool effect for a PC setup villainous Ed Dillinger might appreciate.
If you want to keep things clean when you're setting up a minimal workstation, there is a combination that's always dramatic and that looks singular, thanks to LEDs and a frosted glass desk. A desk made out of this kind of glass will diffuse any lights so that they become ambient instead of directed blinding spots. The good thing about using a frosted glass desk is that the lights are also more visible, allowing you to use them as mood lighting.
The first thing you'll need is a frosted glass desk. The IKEA Vika Lauri is a good option, but it's recently been discontinued. You can find it on Craigslist and eBay easily enough. The Galant desk has a glass tabletop option ($230), but there is no edge to put the LEDs. They'll stand out, so it's best to opt for something with a easier way to hide the LEDs. We've found a few interesting desks on Amazon.
The Techni Mobili L-shaped frosted glass workstation looks promising. It sells for $295.95. Here's another corner desk that would do the trick, but it would actually be cheaper to just try and find a Vika Lauri second-hand. We've seen a few for around $90, so that would be the most sensible option.
As for LEDs, there are a few different types of strips to choose from. Naturally, you could use the IKEA Dioder LED strips, which would match your desk. There are plenty of other LED strips on the market. GE makes some and they are available at The Home Depot. The trick would be to mount them underneath the front and back, and any side of the desk which touch a wall, like a corner. That would allow the lights not to blind anyone else in the room, and you'd use the reflection and glow of the wall as illumination. If this isn't an option for your workstation, then you can mount lights behind your main monitor.
(Images with permission: Flickr member G00gl26)