Fab Fab is one of the fastest growing businesses and for good reason. Items are wonderfully curated in a beautiful easy browsing layout and they just know how to make shopping fun. There's a great gift section organized by price ($25 and under, $50 to $100, etc) that'll ensure you find something unique for the person that has everything. They also just launched free quick dispatch shipping for orders over $75. Download the Fab iPad app for a great shopping experience.
Baggu Get your friends something useful and responsible. The reusable, smartly-foldable, grocery bags made them famous but they're lineup of totes, pouches, and even macbook cases are made to last and come in an assortment of fun colors and patterns.
West Elm Market This new brand from West Elm focuses on home utility goods for everything from your kitchen to your garden. Items have that traditional West Elm appeal and provide color and variety to objects as mundane as garden hoses and hammers.
Gilt Gilt was one of the original flash sale sites and they get things right by offering real discounts and a simple layout that is gorgeous to look at. Their goods come in at a wide range of price points, and they feature several gift sections (for him , for her, for kids) that'll get you on the right track for the holidays. Their iPad app is also fantastic.
Etsy This year was all about celebrating tradition and handmade products. The best resource for hand-crafted goods is still Etsy and they have a great gift ideas section that'll have your shopping cart filled with one-of-a-kind items from artists and makers around the world.
(Images: Chris Perez using sources as linked)