Having more than one monitor is really handy when you work from home. However, sometimes, and sadly more often than we would like, multi-monitor workstations tend to look like air traffic control centers. It's hard to make them look clean and uncluttered.
Let's be honest. A lot of us just want more screen real estate. To be able to run more than one monitor on your desktop, you need some good graphics cards to run things smoothly. Some of the higher end gaming cards offer multi-monitor support. Having more screen real estate means that more apps and docs can be open at the same time. Logically, you'll need a desktop that can support all of this.
We really like yogaxl's home office. He combined dark colors with ample desk space and topped it off with a 78" arch of viewing, thanks to his three 26" monitors. Naturally, a setup like this is perfect to play games, but we're more interested in the usability of all of these monitors. It's true that that if you have more than 4 monitors, things can get distracting. One of the easiest ways of simulating a multi monitor setup is just to use another computer with another monitor. You don't really get most of the benefits, but it's an easy way of almost getting it.
You'll get the best results if you have a high spec desktop with a few video cards. All of his monitors are hooked up to his desktop. He's got three SLI graphic cards running at the same time. Yogaxl used an IKEA Vika desk as a basis for his office. He used a couple of Mikael drawers on wheels for handy storage under his desk. That funky looking lamp on his desk, the bluish ball, is an Ambient Orb, which can be programmed to change colors depending on the weather, the stock market and more. It provides his office with perfect ambient lighting while the screens work their magic. The finishing touches include wallpapers for all that screen real estate from NASA.
Check out how Call of Duty 5 looks on three screens at 5760 x 1200: