First, take stock. Look around you, figure out what's blocking you and try and determine if you're holding onto it for emotional reasons. Having an outsider's pair of eyes can really help you spot what's in the way.
Another step is to calculate the value of each square foot of your house (and if you work from home, you probably already know this from doing taxes). Then, see how much of that space can't be used because it's filled with junk.
Next, Walsh recommends calculating the value of the items in every room to determine what you're still paying off, via credit cards, because the worry and stress has a cost as well.
And speaking of trash - as a bonus, check out Lifehacker's tip for forcing a computer trash can empty when you get the "Trash Cannot Be Emptied" error message in Mac OS X or Windows.
More De-cluttering On Unplggd
How to De-clutter Your Desk in 4 Easy Steps
Declutter Tech By Following The Rule of One
Declutter Your Bag With Gadget Organizers
How To Declutter The Laundry Area
Living Minimally With Tech
(Image: Flickr member smemon87 licensed for use under Creative Commons. Chair image: Flickr member florriebassingbourn licensed for use under Creative Commons. Boxes image: Flickr member macattck licensed for use under Creative Commons)