The house used in the John Hughes film Home Alone is located in the tony Chicago suburb of Winnetka. It's been for sale for a few months but if you don't live in the Chicago region, perhaps you'd be interested in having the house built elsewhere:
Brandon Smith of design firm Southgate Residential is offering the plans for the iconic house featured in Home Alone. The exterior of the house is a complete facsimile of the original home, but Brandon has updated the interior space to include plenty of room for mod cons. Since the original home was built in 1920, it's seriously lacking in closets and the layout undoubtedly features a lot of little rooms, as was the the style then. The updated version of the house features an open floorplan downstairs and four bedrooms with plenty of closets upstairs.
Source: Gapers Block
Images: Southgate Residential