It's a big project to take on, but the result of pouring your own desktop is worth it. With a few foam-wrapped PVC pipes, you can place wire-management holes anywhere in the desk you need them. Plus, if you take a cue from the project's creator, you can add cool stuff like fiber-optic lit glass pieces! How's that for custom?!
If you feel like taking the probably messy plunge, head over to Instructables and follow the directions. If you prefer a cleaner (and probably easier) DIY desk, check out "A DIY Sleek Desk that Hides All Your Goodies" or "DIY: Multimedia Desk, Built From 'Scratch'."