For a quick getaway you can't always book a room in that cool new boutique hotel you read about or that out-of-your-pricerange-resort-and-spa, but this is America, and you don't have to settle for a generic chain hotel, we have Bed and Breakfasts:
Bed and Breakfasts generally give you a private room and bathroom and then you share the main areas of the house with the other guests. Anywhere between 2 and 7 rooms of guests could be in a B&B and they serve you a nice, hot breakfast each morning. We love them for the more personal nature of a stay, but certainly they lack certain amenities like a pool or a spa (though some have these). It's easy to get great recommendations for local things to do and you have the sense of being at home away from home (since it is, after all, someone's home).