We haven't. When we head out of town, our dog goes to friends (or comes along) and we are not really "plant people" so that isn't an issue. I think it feels ok because we live in a multi-unit building - we know that someone is always around. How about you - have you had a sitter come keep an eye on things while you hit the road?
For those of you who answered yes, please share any experiences (good or bad) along with your tips for working with a house sitter in the comments below.